Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles
Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles
About this item
Full title
Author / Creator
Wang, Ming , Zuris, John A. , Meng, Fantao , Rees, Holly , Sun, Shuo , Deng, Pu , Han, Yong , Gao, Xue , Pouli, Dimitra , Wu, Qi , Georgakoudi, Irene , Liu, David R. and Xu, Qiaobing
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
A central challenge to the development of protein-based therapeutics is the inefficiency of delivery of protein cargo across the mammalian cell membrane, including escape from endosomes. Here we report that combining bioreducible lipid nanoparticles with negatively supercharged Cre recombinase or anionic Cas9:single-guide (sg)RNA complexes drives t...
Alternative Titles
Full title
Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1805512218
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1805512218
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1520244113
