Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure
Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure
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Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
United States: American Association for the Advancement of Science
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Contents
Phospholipids are asymmetrically distributed in the plasma membrane. This asymmetrical distribution is disrupted during apoptosis, exposing phosphatidylserine (PtdSer) on the cell surface. Using a haploid genetic screen in human cells, we found that ATP11C (adenosine triphosphatase type 11C) and CDC50A (cell division cycle protein 50A) are required...
Alternative Titles
Full title
Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure
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TN_cdi_proquest_miscellaneous_1808124955
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1808124955
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1252809
