The interferon type I signature is present in systemic sclerosis before overt fibrosis and might con...
The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and high collagen synthesis
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Brkic, Zana , van Bon, Lenny , Cossu, Marta , van Helden-Meeuwsen, Cornelia G , Vonk, Madelon C , Knaapen, Hanneke , van den Berg, Wim , Dalm, Virgil A , Van Daele, Paul L , Severino, Adriana , Maria, Naomi I , Guillen, Samara , Dik, Willem A , Beretta, Lorenzo , Versnel, Marjan A and Radstake, Timothy
Publisher
England
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Language
English
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Publisher
England
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BackgroundInterferon (IFN) signature has been reported in definite systemic sclerosis (SSc) but it has not been characterised in early SSc (EaSSc). We aim at characterising IFN type I signature in SSc before overt skin fibrosis develops.MethodsThe expression of 11 IFN type I inducible genes was tested in whole-blood samples from 30 healthy controls...
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The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and high collagen synthesis
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TN_cdi_proquest_miscellaneous_1808666771
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1808666771
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ISSN
0003-4967
E-ISSN
1468-2060
DOI
10.1136/annrheumdis-2015-207392
