Immunomodulatory drugs disrupt the cereblon–CD147–MCT1 axis to exert antitumor activity and teratoge...
Immunomodulatory drugs disrupt the cereblon–CD147–MCT1 axis to exert antitumor activity and teratogenicity
About this item
Full title
Author / Creator
Eichner, Ruth , Heider, Michael , Fernández-Sáiz, Vanesa , van Bebber, Frauke , Garz, Anne-Kathrin , Lemeer, Simone , Rudelius, Martina , Targosz, Bianca-Sabrina , Jacobs, Laura , Knorn, Anna-Maria , Slawska, Jolanta , Platzbecker, Uwe , Germing, Ulrich , Langer, Christian , Knop, Stefan , Einsele, Herrmann , Peschel, Christian , Haass, Christian , Keller, Ulrich , Schmid, Bettina , Götze, Katharina S , Kuster, Bernhard and Bassermann, Florian
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Thalidomide and its derivatives lenalidomide and pomalidomide, which are used to treat multiple myeloma and del(5q) myelodysplastic syndrome, have antitumor and teratogenic effects through a mechanism involving destabilization of the CD147 and MCT1 proteins.
Immunomodulatory drugs (IMiDs), such as thalidomide and its derivatives lenalidomide and...
Alternative Titles
Full title
Immunomodulatory drugs disrupt the cereblon–CD147–MCT1 axis to exert antitumor activity and teratogenicity
Authors, Artists and Contributors
Author / Creator
Heider, Michael
Fernández-Sáiz, Vanesa
van Bebber, Frauke
Garz, Anne-Kathrin
Lemeer, Simone
Rudelius, Martina
Targosz, Bianca-Sabrina
Jacobs, Laura
Knorn, Anna-Maria
Slawska, Jolanta
Platzbecker, Uwe
Germing, Ulrich
Langer, Christian
Knop, Stefan
Einsele, Herrmann
Peschel, Christian
Haass, Christian
Keller, Ulrich
Schmid, Bettina
Götze, Katharina S
Kuster, Bernhard
Bassermann, Florian
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1808728124
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1808728124
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4128
