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ArticlesPeer ReviewedFull Text
Current challenges and unmet medical needs in myelodysplastic syndromes
Author / Creator:Platzbecker, Uwe ; Kubasch, Anne Sophie ; Homer-Bouthiette, Collin ; Prebet, Thomas
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2021-08, Vol.35 (8), p.2182-2198
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Setting Fire to ESA and EMA Resistance: New Targeted Treatment Options in Lower Risk Myelodysplastic Syndromes
Author / Creator:Kubasch, Anne Sophie ; Platzbecker, Uwe
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2019-08, Vol.20 (16), p.3853
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Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes
Author / Creator:Fenaux, Pierre ; Platzbecker, Uwe ; Mufti, Ghulam J ; Garcia-Manero, Guillermo ; Buckstein, Rena ; Santini, Valeria ; Díez-Campelo, María ; Finelli, Carlo ; Cazzola, Mario ; Ilhan, Osman ; Sekeres, Mikkael A ; Falantes, José F ; Arrizabalaga, Beatriz ; Salvi, Flavia ; Giai, Valentina ; Vyas, Paresh ; Bowen, David ; Selleslag, Dominik ; DeZern, Amy E ; Jurcic, Joseph G ; Germing, Ulrich ; Götze, Katharina S ; Quesnel, Bruno ; Beyne-Rauzy, Odile ; Cluzeau, Thomas ; Voso, Maria-Teresa ; Mazure, Dominiek ; Vellenga, Edo ; Greenberg, Peter L ; Hellström-Lindberg, Eva ; Zeidan, Amer M ; Adès, Lionel ; Verma, Amit ; Savona, Michael R ; Laadem, Abderrahmane ; Benzohra, Aziz ; Zhang, Jennie ; Rampersad, Anita ; Dunshee, Diana R ; Linde, Peter G ; Sherman, Matthew L ; Komrokji, Rami S ; List, Alan F
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2020-01, Vol.382 (2), p.140-151
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Measurable residual disease-guided treatment with azacitidine to prevent haematological relapse in patients with myelodysplastic syndrome and acute myeloid leukaemia (RELAZA2): an open-label, multicen...
Author / Creator:Platzbecker, Uwe, Prof ; Middeke, Jan Moritz, MD ; Sockel, Katja, MD ; Herbst, Regina, MD ; Wolf, Dominik, Prof ; Baldus, Claudia D, Prof ; Oelschlägel, Uta, PhD ; Mütherig, Anke, MD ; Fransecky, Lars, MD ; Noppeney, Richard, MD ; Bug, Gesine, MD ; Götze, Katharina S, Prof ; Krämer, Alwin, Prof ; Bochtler, Tilmann, MD ; Stelljes, Matthias, Prof ; Groth, Christoph, MD ; Schubert, Antje, PhD ; Mende, Marika, MD ; Stölzel, Friedrich, MD ; Borkmann, Christine, MD ; Kubasch, Anne Sophie, MD ; von Bonin, Malte, MD ; Serve, Hubert, Prof ; Hänel, Mathias, MD ; Dührsen, Ulrich, MD ; Schetelig, Johannes, Prof ; Röllig, Christoph, MD ; Kramer, Michael, MSc ; Ehninger, Gerhard, Prof ; Bornhäuser, Martin, Prof ; Thiede, Christian, Prof
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2018-12, Vol.19 (12), p.1668-1679
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Efficacy and safety of avapritinib in advanced systemic mastocytosis: interim analysis of the phase 2 PATHFINDER trial
Author / Creator:Gotlib, Jason ; Reiter, Andreas ; Radia, Deepti H. ; Deininger, Michael W. ; George, Tracy I. ; Panse, Jens ; Vannucchi, Alessandro M. ; Platzbecker, Uwe ; Alvarez-Twose, Iván ; Mital, Andrzej ; Hermine, Olivier ; Dybedal, Ingunn ; Hexner, Elizabeth O. ; Hicks, Lisa K. ; Span, Lambert ; Mesa, Ruben ; Bose, Prithviraj ; Pettit, Kristen M. ; Heaney, Mark L. ; Oh, Stephen T. ; Sen, Jayita ; Lin, Hui-Min ; Mar, Brenton G. ; DeAngelo, Daniel J.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2021-12, Vol.27 (12), p.2192-2199
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Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B-8800 in myeloid neoplasms
Author / Creator:Steensma, David P. ; Wermke, Martin ; Klimek, Virginia M. ; Greenberg, Peter L. ; Font, Patricia ; Komrokji, Rami S. ; Yang, Jay ; Brunner, Andrew M. ; Carraway, Hetty E. ; Ades, Lionel ; Al-Kali, Aref ; Alonso-Dominguez, Juan M. ; Alfonso-Piérola, Ana ; Coombs, Catherine C. ; Deeg, H. Joachim ; Flinn, Ian ; Foran, James M. ; Garcia-Manero, Guillermo ; Maris, Michael B. ; McMasters, Malgorzata ; Micol, Jean-Baptiste ; De Oteyza, Jaime Perez ; Thol, Felicitas ; Wang, Eunice S. ; Watts, Justin M. ; Taylor, Justin ; Stone, Richard ; Gourineni, Vikram ; Marino, Alyssa J. ; Yao, Huilan ; Destenaves, Benoit ; Yuan, Xiaobin ; Yu, Kun ; Dar, Sara ; Ohanjanian, Lernik ; Kuida, Keisuke ; Xiao, Jianjun ; Scholz, Catherine ; Gualberto, Antonio ; Platzbecker, Uwe
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2021-12, Vol.35 (12), p.3542-3550
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ArticlesPeer ReviewedFull Text
Luspatercept: A peaceful revolution in the standard of care for myelodysplastic neoplasms
Author / Creator:Vinchi, Francesca ; Platzbecker, Uwe
Publisher:United States: John Wiley & Sons, Inc
Journal title:HemaSphere, 2024-03, Vol.8 (3), p.e41-n/a
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ArticlesPeer ReviewedFull Text
Redefining and measuring transplant conditioning intensity in current era: a study in acute myeloid leukemia patients
Author / Creator:Spyridonidis, Alexandros ; Labopin, Myriam ; Savani, Bipin N. ; Niittyvuopio, Riitta ; Blaise, Didier ; Craddock, Charles ; Socié, Gerard ; Platzbecker, Uwe ; Beelen, Dietrich ; Milpied, Noel ; Cornelissen, Jan J. ; Ganser, Arnold ; Huynh, Anne ; Griskevicius, Laimonas ; Giebel, Sebastian ; Aljurf, Mahmoud ; Brissot, Eolia ; Malard, Florent ; Esteve, Jordi ; Peric, Zinaida ; Baron, Frédéric ; Ruggeri, Annalisa ; Schmid, Christoph ; Gilleece, Maria ; Gorin, Norbert-Claude ; Lanza, Francesco ; Shouval, Roni ; Versluis, Jurjen ; Bug, Gesine ; Fløisand, Yngvar ; Ciceri, Fabio ; Sanz, Jamie ; Bazarbachi, Ali ; Nagler, Arnon ; Mohty, Mohamad
Publisher:London: Nature Publishing Group UK
Journal title:Bone marrow transplantation (Basingstoke), 2020-06, Vol.55 (6), p.1114-1125
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ArticlesPeer ReviewedFull Text
Loss of lenalidomide-induced megakaryocytic differentiation leads to therapy resistance in del(5q) myelodysplastic syndrome
Author / Creator:Martinez-Høyer, Sergio ; Deng, Yu ; Parker, Jeremy ; Jiang, Jihong ; Mo, Angela ; Docking, T. Roderick ; Gharaee, Nadia ; Li, Jenny ; Umlandt, Patricia ; Fuller, Megan ; Jädersten, Martin ; Kulasekararaj, Austin ; Malcovati, Luca ; List, Alan F. ; Hellström-Lindberg, Eva ; Platzbecker, Uwe ; Karsan, Aly
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2020-05, Vol.22 (5), p.526-533
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ELN risk stratification and outcomes in secondary and therapy-related AML patients consolidated with allogeneic stem cell transplantation
Author / Creator:Jentzsch, Madlen ; Grimm, Juliane ; Bill, Marius ; Brauer, Dominic ; Backhaus, Donata ; Goldmann, Karoline ; Schulz, Julia ; Niederwieser, Dietger ; Platzbecker, Uwe ; Schwind, Sebastian
Publisher:London: Nature Publishing Group UK
Journal title:Bone marrow transplantation (Basingstoke), 2021-04, Vol.56 (4), p.936-945
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ArticlesPeer ReviewedFull Text
Immunomodulatory drugs disrupt the cereblon–CD147–MCT1 axis to exert antitumor activity and teratogenicity
Author / Creator:Eichner, Ruth ; Heider, Michael ; Fernández-Sáiz, Vanesa ; van Bebber, Frauke ; Garz, Anne-Kathrin ; Lemeer, Simone ; Rudelius, Martina ; Targosz, Bianca-Sabrina ; Jacobs, Laura ; Knorn, Anna-Maria ; Slawska, Jolanta ; Platzbecker, Uwe ; Germing, Ulrich ; Langer, Christian ; Knop, Stefan ; Einsele, Herrmann ; Peschel, Christian ; Haass, Christian ; Keller, Ulrich ; Schmid, Bettina ; Götze, Katharina S ; Kuster, Bernhard ; Bassermann, Florian
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2016-07, Vol.22 (7), p.735-743
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ArticlesPeer ReviewedFull Text
Investigation of measurable residual disease in acute myeloid leukemia by DNA methylation patterns
Author / Creator:Božić, Tanja ; Kuo, Chao-Chung ; Hapala, Jan ; Franzen, Julia ; Eipel, Monika ; Platzbecker, Uwe ; Kirschner, Martin ; Beier, Fabian ; Jost, Edgar ; Thiede, Christian ; Wagner, Wolfgang
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2022-01, Vol.36 (1), p.80-89
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A proof of concept phase I/II pilot trial of LSD1 inhibition by tranylcypromine combined with ATRA in refractory/relapsed AML patients not eligible for intensive therapy
Author / Creator:Wass, Maxi ; Göllner, Stefanie ; Besenbeck, Birgit ; Schlenk, Richard F. ; Mundmann, Petra ; Göthert, Joachim R. ; Noppeney, Richard ; Schliemann, Christoph ; Mikesch, Jan-Henrik ; Lenz, Georg ; Dugas, Martin ; Wermke, Martin ; Röllig, Christoph ; Bornhäuser, Martin ; Serve, Hubert ; Platzbecker, Uwe ; Foerster, Kathrin I. ; Burhenne, Jürgen ; Haefeli, Walter E. ; Müller, Lutz P. ; Binder, Mascha ; Pabst, Caroline ; Müller-Tidow, Carsten
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2021-03, Vol.35 (3), p.701-711
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ArticlesPeer ReviewedFull Text
Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome
Author / Creator:Ribezzo, Flavia ; Snoeren, Inge A. M. ; Ziegler, Susanne ; Stoelben, Jacques ; Olofsen, Patricia A. ; Henic, Almira ; Ferreira, Monica Ventura ; Chen, Si ; Stalmann, Ursula S. A. ; Buesche, Guntram ; Hoogenboezem, Remco M. ; Kramann, Rafael ; Platzbecker, Uwe ; Raaijmakers, Marc H. G. P. ; Ebert, Benjamin L. ; Schneider, Rebekka K.
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2019-07, Vol.33 (7), p.1759-1772
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Long-term survival after intensive chemotherapy or hypomethylating agents in AML patients aged 70 years and older: a large patient data set study from European registries
Author / Creator:Récher, Christian ; Röllig, Christoph ; Bérard, Emilie ; Bertoli, Sarah ; Dumas, Pierre-Yves ; Tavitian, Suzanne ; Kramer, Michael ; Serve, Hubert ; Bornhäuser, Martin ; Platzbecker, Uwe ; Müller-Tidow, Carsten ; Baldus, Claudia D. ; Martínez-Cuadrón, David ; Serrano, Josefina ; Martínez-Sánchez, Pilar ; Arbolí, Eduardo Rodríguez ; Gil, Cristina ; Bergua, Juan ; Bernal, Teresa ; de la Fuente Burguera, Adolfo ; Delabesse, Eric ; Bidet, Audrey ; Pigneux, Arnaud ; Montesinos, Pau
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2022-04, Vol.36 (4), p.913-922
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ArticlesPeer ReviewedFull Text
Machine learning assisted real-time deformability cytometry of CD34+ cells allows to identify patients with myelodysplastic syndromes
Author / Creator:Herbig, Maik ; Jacobi, Angela ; Wobus, Manja ; Weidner, Heike ; Mies, Anna ; Kräter, Martin ; Otto, Oliver ; Thiede, Christian ; Weickert, Marie‑Theresa ; Götze, Katharina S. ; Rauner, Martina ; Hofbauer, Lorenz C. ; Bornhäuser, Martin ; Guck, Jochen ; Ader, Marius ; Platzbecker, Uwe ; Balaian, Ekaterina
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-01, Vol.12 (1), p.870-8, Article 870
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Luspatercept restores SDF-1-mediated hematopoietic support by MDS-derived mesenchymal stromal cells
Author / Creator:Wobus, Manja ; Mies, Anna ; Asokan, Nandini ; Oelschlägel, Uta ; Möbus, Kristin ; Winter, Susann ; Cross, Michael ; Weidner, Heike ; Rauner, Martina ; Hofbauer, Lorenz C. ; Bornhäuser, Martin ; Platzbecker, Uwe
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2021-10, Vol.35 (10), p.2936-2947
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Deep learning identifies Acute Promyelocytic Leukemia in bone marrow smears
Author / Creator:Eckardt, Jan-Niklas ; Schmittmann, Tim ; Riechert, Sebastian ; Kramer, Michael ; Sulaiman, Anas Shekh ; Sockel, Katja ; Kroschinsky, Frank ; Schetelig, Johannes ; Wagenführ, Lisa ; Schuler, Ulrich ; Platzbecker, Uwe ; Thiede, Christian ; Stölzel, Friedrich ; Röllig, Christoph ; Bornhäuser, Martin ; Wendt, Karsten ; Middeke, Jan Moritz
Publisher:England: BioMed Central Ltd
Journal title:BMC cancer, 2022-02, Vol.22 (1), p.201-201, Article 201
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Sorafenib or placebo in patients with newly diagnosed acute myeloid leukaemia: long-term follow-up of the randomized controlled SORAML trial
Author / Creator:Röllig, Christoph ; Serve, Hubert ; Noppeney, Richard ; Hanoun, Maher ; Krug, Utz ; Baldus, Claudia D. ; Brandts, Christian H. ; Kunzmann, Volker ; Einsele, Hermann ; Krämer, Alwin ; Müller-Tidow, Carsten ; Schäfer-Eckart, Kerstin ; Neubauer, Andreas ; Burchert, Andreas ; Giagounidis, Aristoteles ; Krause, Stefan W. ; Mackensen, Andreas ; Aulitzky, Walter ; Herbst, Regina ; Hänel, Mathias ; Frickhofen, Norbert ; Kullmer, Johannes ; Kaiser, Ulrich ; Kiani, Alexander ; Link, Hartmut ; Geer, Thomas ; Reichle, Albrecht ; Junghanß, Christian ; Repp, Roland ; Meinhardt, Achim ; Dürk, Heinz ; Klut, Ina-Maria ; Bornhäuser, Martin ; Schaich, Markus ; Parmentier, Stefani ; Görner, Martin ; Thiede, Christian ; von Bonin, Malte ; Platzbecker, Uwe ; Schetelig, Johannes ; Kramer, Michael ; Berdel, Wolfgang E. ; Ehninger, Gerhard
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2021-09, Vol.35 (9), p.2517-2525
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Long-term results of all-trans retinoic acid and arsenic trioxide in non-high-risk acute promyelocytic leukemia: update of the APL0406 Italian-German randomized trial
Author / Creator:Cicconi, Laura ; Platzbecker, Uwe ; Avvisati, Giuseppe ; Paoloni, Francesca ; Thiede, Christian ; Vignetti, Marco ; Fazi, Paola ; Ferrara, Felicetto ; Divona, Mariadomenica ; Albano, Francesco ; Efficace, Fabio ; Sborgia, Marco ; Di Bona, Eros ; Breccia, Massimo ; Borlenghi, Erika ; Cairoli, Roberto ; Rambaldi, Alessandro ; Melillo, Lorella ; La Nasa, Giorgio ; Fiedler, Walter ; Brossart, Peter ; Hertenstein, Bernd ; Salih, Helmut R. ; Annibali, Ombretta ; Wattad, Mohammed ; Lubbert, Michael ; Brandts, Christian H. ; Hanel, Mathias ; Rollig, Christoph ; Schmitz, Norbert ; Link, Hartmut ; Frairia, Chiara ; Fozza, Claudio ; Maria D’Arco, Alfonso ; Di Renzo, Nicola ; Cortelezzi, Agostino ; Fabbiano, Francesco ; Dohner, Konstanze ; Ganser, Arnold ; Dohner, Hartmut ; Amadori, Sergio ; Mandelli, Franco ; Voso, Maria Teresa ; Ehninger, Gerhard ; Schlenk, Richard F. ; Lo-Coco, Francesco
Publisher:London: Nature Publishing Group UK
Journal title:Leukemia, 2020-03, Vol.34 (3), p.914-918
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Current challenges and unmet medical needs in myelodysplastic syndromes

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Setting Fire to ESA and EMA Resistance: New Targeted Treatment Options in Lower Risk Myelodysplastic Syndromes

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Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes

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Measurable residual disease-guided treatment with azacitidine to prevent haematological relapse in patients with myelodysplastic syndrome and acute myeloid leukaemia (RELAZA2): an open-label, multicen...

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Efficacy and safety of avapritinib in advanced systemic mastocytosis: interim analysis of the phase 2 PATHFINDER trial

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Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B-8800 in myeloid neoplasms

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Luspatercept: A peaceful revolution in the standard of care for myelodysplastic neoplasms

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Redefining and measuring transplant conditioning intensity in current era: a study in acute myeloid leukemia patients

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Loss of lenalidomide-induced megakaryocytic differentiation leads to therapy resistance in del(5q) myelodysplastic syndrome

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ELN risk stratification and outcomes in secondary and therapy-related AML patients consolidated with allogeneic stem cell transplantation

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Immunomodulatory drugs disrupt the cereblon–CD147–MCT1 axis to exert antitumor activity and teratogenicity

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Investigation of measurable residual disease in acute myeloid leukemia by DNA methylation patterns

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A proof of concept phase I/II pilot trial of LSD1 inhibition by tranylcypromine combined with ATRA in refractory/relapsed AML patients not eligible for intensive therapy

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Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome

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Long-term survival after intensive chemotherapy or hypomethylating agents in AML patients aged 70 years and older: a large patient data set study from European registries

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Machine learning assisted real-time deformability cytometry of CD34+ cells allows to identify patients with myelodysplastic syndromes

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Luspatercept restores SDF-1-mediated hematopoietic support by MDS-derived mesenchymal stromal cells

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Deep learning identifies Acute Promyelocytic Leukemia in bone marrow smears

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Sorafenib or placebo in patients with newly diagnosed acute myeloid leukaemia: long-term follow-up of the randomized controlled SORAML trial

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Long-term results of all-trans retinoic acid and arsenic trioxide in non-high-risk acute promyelocytic leukemia: update of the APL0406 Italian-German randomized trial

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