Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi
Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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A systematic analysis reveals some genetic variation underpinning the heterogeneity in pathogen-induced cytokine production by blood cells from a cohort of healthy individuals.
Little is known about the inter-individual variation of cytokine responses to different pathogens in healthy individuals. To systematically describe cytokine responses elicited by distinct pathogens and to determine the effect of genetic variation on cytokine production, we profiled cytokines produced by peripheral blood mononuclear cells from 197 individuals of European origin from the 200 Functional Genomics (200FG) cohort in the Human Functional Genomics Project (
http://www.humanfunctionalgenomics.org
), obtained over three different years. We compared bacteria- and fungi-induced cytokine profiles and found that most cytokine responses were organized around a physiological response to specific pathogens, rather than around a particular immune pathway or cytokine. We then correlated genome-wide single-nucleotide polymorphism (SNP) genotyp...
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Full title
Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi
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TN_cdi_proquest_miscellaneous_1811888115
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1811888115
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4139
