Histone Deacetylase Inhibitors Reduce Polyglutamine Toxicity
Histone Deacetylase Inhibitors Reduce Polyglutamine Toxicity
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Full title
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Polyglutamine diseases include at least nine neurodegenerative disorders, each caused by a CAG repeat expansion in a different gene. Accumulation of mutant polyglutamine-containing proteins occurs in patients, and evidence from cell culture and animal experiments suggests the nucleus as a site of pathogenesis. To understand the consequences of nucl...
Alternative Titles
Full title
Histone Deacetylase Inhibitors Reduce Polyglutamine Toxicity
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Record Identifier
TN_cdi_proquest_miscellaneous_18232530
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_18232530
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.261400698
