Frizzled proteins are colonic epithelial receptors for C. difficile toxin B
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Clostridium difficile
toxin B (TcdB) is a critical virulence factor that causes diseases associated with
C. difficile
infection. Here we carried out CRISPR–Cas9-mediated genome-wide screens and identified the members of the Wnt receptor frizzled family (FZDs) as TcdB receptors. TcdB binds to the conserved Wnt-binding site known as the cyst...
Alternative Titles
Full title
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B
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TN_cdi_proquest_miscellaneous_1835360051
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1835360051
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature19799
