Ligand-accelerated enantioselective methylene C(sp³)-H bond activation
Ligand-accelerated enantioselective methylene C(sp³)-H bond activation
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Author / Creator
Chen, Gang , Gong, Wei , Zhuang, Zhe , Andrä, Michal S. , Chen, Yan-Qiao , Hong, Xin , Yang, Yun-Fang , Liu, Tao , Houk, K. N. and Yu, Jin-Quan
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: American Association for the Advancement of Science
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Scope and Contents
Contents
Effective differentiation of prochiral carbon-hydrogen (C-H) bonds on a single methylene carbon via asymmetric metal insertion remains a challenge. Here, we report the discovery of chiral acetyl-protected aminoethyl quinoline ligands that enable asymmetric palladium insertion into prochiral C-H bonds on a single methylene carbon center. We apply th...
Alternative Titles
Full title
Ligand-accelerated enantioselective methylene C(sp³)-H bond activation
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Record Identifier
TN_cdi_proquest_miscellaneous_1835611755
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1835611755
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aaf4434
