Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor
Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor
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Publisher
United States: American Association for the Advancement of Science
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English
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United States: American Association for the Advancement of Science
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Contents
The ongoing Zika virus (ZIKV) outbreak is linked to severe neurological disorders. ZIKV relies on its NS2B/NS3 protease for polyprotein processing; hence, this enzyme is an attractive drug target. The 2.7 angstrom crystal structure of ZIKV protease in complex with a peptidomimetic boronic acid inhibitor reveals a cyclic diester between the boronic...
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Full title
Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor
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TN_cdi_proquest_miscellaneous_1835629970
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1835629970
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aag2419
