Altered metabolite levels in cancer: implications for tumour biology and cancer therapy
Altered metabolite levels in cancer: implications for tumour biology and cancer therapy
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Key Points
Cancer-associated expression changes and mutations in metabolic enzymes can alter levels of metabolites.
The accumulation of certain metabolites can support cancer cell proliferation by increasing flux through anabolic metabolism.
Competitive inhibition of α-ketoglutarate-dependent dioxygenases by 2-hydroxyglutarate (2HG), succi...
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Full title
Altered metabolite levels in cancer: implications for tumour biology and cancer therapy
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TN_cdi_proquest_miscellaneous_1837325426
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1837325426
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ISSN
1474-175X
E-ISSN
1474-1768
DOI
10.1038/nrc.2016.85
