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Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with...

Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1837339679

Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline

About this item

Full title

Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline

Publisher

London: Nature Publishing Group UK

Journal title

Oncogene, 2016-10, Vol.35 (43), p.5663-5673

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western countries and is currently incurable due, in part, to difficulty in eliminating the leukemia cells protected by stromal microenvironment. Based on previous observations that CLL cells exhibit mitochondrial dysfunction and altered lipid metabolism and that carnitine...

Alternative Titles

Full title

Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1837339679

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1837339679

Other Identifiers

ISSN

0950-9232

E-ISSN

1476-5594

DOI

10.1038/onc.2016.103

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