Huntington's Disease Age-of-Onset Linked to Polyglutamine Aggregation Nucleation
Huntington's Disease Age-of-Onset Linked to Polyglutamine Aggregation Nucleation
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
In Huntington's Disease and related expanded CAG repeat diseases, a polyglutamine [poly(Gln)] sequence containing 36 repeats in the corresponding disease protein is benign, whereas a sequence with only 2-3 additional glutamines is associated with disease risk. Above this threshold range, longer repeat lengths are associated with earlier ages-of-ons...
Alternative Titles
Full title
Huntington's Disease Age-of-Onset Linked to Polyglutamine Aggregation Nucleation
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Record Identifier
TN_cdi_proquest_miscellaneous_18585516
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_18585516
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.182276099
