Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia
Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia
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Author / Creator
Fang, Jing , Bolanos, Lyndsey C , Choi, Kwangmin , Liu, Xiaona , Christie, Susanne , Akunuru, Shailaja , Kumar, Rupali , Wang, Dehua , Chen, Xiaoting , Greis, Kenneth D , Stoilov, Peter , Filippi, Marie-Dominique , Maciejewski, Jaroslaw P , Garcia-Manero, Guillermo , Weirauch, Matthew T , Salomonis, Nathan , Geiger, Hartmut , Zheng, Yi and Starczynowski, Daniel T
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Starczynowski and colleagues show that overexpression of TRAF6 in HSCs induces ubiquitination of the RNA-binding protein hnRNPA1 and alternative splicing of Arhgap1, which accounts for the hematopoietic defects in myelodysplastic syndromes.
Toll-like receptor (TLR) activation contributes to premalignant hematologic conditions, such as myelodyspl...
Alternative Titles
Full title
Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia
Authors, Artists and Contributors
Author / Creator
Bolanos, Lyndsey C
Choi, Kwangmin
Liu, Xiaona
Christie, Susanne
Akunuru, Shailaja
Kumar, Rupali
Wang, Dehua
Chen, Xiaoting
Greis, Kenneth D
Stoilov, Peter
Filippi, Marie-Dominique
Maciejewski, Jaroslaw P
Garcia-Manero, Guillermo
Weirauch, Matthew T
Salomonis, Nathan
Geiger, Hartmut
Zheng, Yi
Starczynowski, Daniel T
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1868315595
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1868315595
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.3654
