Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease
Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Complement-activating glycosylceramide-specific autoantibodies drive a self-propagating cycle of glycosylceramide accumulation and inflammation in Gaucher disease.
The cause of inflammation in Gaucher disease
Gaucher disease is a lysosomal storage disorder in which mutations in the
GBA1
gene lead to the accumulation of glycosylceramide...
Alternative Titles
Full title
Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease
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TN_cdi_proquest_miscellaneous_1871550719
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1871550719
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature21368
