Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases
Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Forkhead family transcription factors are critical regulators of cell cycle progression and apoptosis in hematopoietic cells. Here, we show that FOXO3a (also known as FKHRL1) is a new substrate of caspase-3-like proteases during apoptosis in T lymphocytes. FOXO3a was cleaved
in vivo
by caspases in leukemic Jurkat cells following engagement of...
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Full title
Proteolytic regulation of Forkhead transcription factor FOXO3a by caspase-3-like proteases
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TN_cdi_proquest_miscellaneous_18811525
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_18811525
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/sj.onc.1206778
