Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical o...
Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites
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United States: American Institute of Physics, Inc
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Language
English
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Publisher
United States: American Institute of Physics, Inc
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Crystallographic fragment screening uses low molecular weight compounds to probe the protein surface and although individual protein-fragment interactions are high quality, fragments commonly bind at low occupancy, historically making identification difficult. However, our new Pan-Dataset Density Analysis method readily identifies binders missed by...
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Full title
Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites
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TN_cdi_proquest_miscellaneous_1881449684
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1881449684
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ISSN
2329-7778
E-ISSN
2329-7778
DOI
10.1063/1.4974176
