A nontoxic pain killer designed by modeling of pathological receptor conformations
A nontoxic pain killer designed by modeling of pathological receptor conformations
About this item
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Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: American Association for the Advancement of Science
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Scope and Contents
Contents
Indiscriminate activation of opioid receptors provides pain relief but also severe central and intestinal side effects. We hypothesized that exploiting pathological (rather than physiological) conformation dynamics of opioid receptor-ligand interactions might yield ligands without adverse actions. By computer simulations at low pH, a hallmark of in...
Alternative Titles
Full title
A nontoxic pain killer designed by modeling of pathological receptor conformations
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Record Identifier
TN_cdi_proquest_miscellaneous_1893905621
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1893905621
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aai8636
