Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabil...
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation
About this item
Full title
Author / Creator
Zhang, Pingzhao , Wang, Dejie , Zhao, Yu , Ren, Shancheng , Gao, Kun , Ye, Zhenqing , Wang, Shangqian , Pan, Chun-Wu , Zhu, Yasheng , Yan, Yuqian , Yang, Yinhui , Wu, Di , He, Yundong , Zhang, Jun , Lu, Daru , Liu, Xiuping , Yu, Long , Zhao, Shimin , Li, Yao , Lin, Dong , Wang, Yuzhuo , Wang, Liguo , Chen, Yu , Sun, Yinghao , Wang, Chenji and Huang, Haojie
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Mutations in
SPOP
, the gene encoding a component of the E3 ubiquitin ligase complex, impair ubiquitination-dependent degradation of BRD2, BRD3 and BRD4 proteins and result in activation of ATK–mTORC1 signaling and resistance to BET inhibitors. Pharmacological blockade of AKT represents a viable strategy to restore the sensitivity of SPOP-mut...
Alternative Titles
Full title
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation
Authors, Artists and Contributors
Author / Creator
Wang, Dejie
Zhao, Yu
Ren, Shancheng
Gao, Kun
Ye, Zhenqing
Wang, Shangqian
Pan, Chun-Wu
Zhu, Yasheng
Yan, Yuqian
Yang, Yinhui
Wu, Di
He, Yundong
Zhang, Jun
Lu, Daru
Liu, Xiuping
Yu, Long
Zhao, Shimin
Li, Yao
Lin, Dong
Wang, Yuzhuo
Wang, Liguo
Chen, Yu
Sun, Yinghao
Wang, Chenji
Huang, Haojie
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1928783065
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1928783065
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4379
