Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligon...
Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
A scalable chemical method to control phosphorothioate chirality demonstrates its impact on the efficacy of antisense oligonucleotides.
Whereas stereochemical purity in drugs has become the standard for small molecules, stereoisomeric mixtures containing as many as a half million components persist in antisense oligonucleotide (ASO) therapeutics...
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Full title
Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides
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TN_cdi_proquest_miscellaneous_1931241942
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1931241942
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ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt.3948
