Patient-derived xenografts undergo mouse-specific tumor evolution
Patient-derived xenografts undergo mouse-specific tumor evolution
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
This large-scale analysis of copy number alterations (CNAs) in patient-derived xenografts (PDXs) across 24 cancer types shows that new CNAs accumulate quickly and that the specific CNAs acquired during passaging differ from those acquired during tumor evolution in patients, suggesting that PDX tumors are under distinct selection pressures from tumo...
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Full title
Patient-derived xenografts undergo mouse-specific tumor evolution
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TN_cdi_proquest_miscellaneous_1949084333
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1949084333
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.3967
