Evaluation of the effects of hydrophilic organic solvents on CYP3A-mediated drug-drug interaction in...
Evaluation of the effects of hydrophilic organic solvents on CYP3A-mediated drug-drug interaction in vitro
About this item
Full title
Author / Creator
Iwase, M , Kurata, N , Ehana, R , Nishimura, Y , Masamoto, T and Yasuhara, H
Publisher
Thousand Oaks, CA: SAGE Publications
Journal title
Language
English
Formats
Publication information
Publisher
Thousand Oaks, CA: SAGE Publications
Subjects
More information
Scope and Contents
Contents
This study evaluated the effects of the commonly used hydrophilic organic solvents, acetonitrile, methanol, ethanol, 1-propanol, dimethyl sulfoxide (DMSO), N,N-dimethylformamide, polyethylene glycol and propylene glycol, on CYP3A in pooled human liver microsomes, using testosterone and midazolam as substrates. Furthermore, we examined the modulatio...
Alternative Titles
Full title
Evaluation of the effects of hydrophilic organic solvents on CYP3A-mediated drug-drug interaction in vitro
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_19564667
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_19564667
Other Identifiers
ISSN
0960-3271
E-ISSN
1477-0903
DOI
10.1177/0960327106071979
