Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM
Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Cryo-electron microscopy mapping of the calcium-activated chloride channel TMEM16A combined with functional experiments reveals that calcium ions interact directly with the pore to activate the channel.
TMEM16A structure solved
The diverse TMEM16 membrane protein family contains Ca(
II
)-activated chloride channels, lipid scramblases an...
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Full title
Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM
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TN_cdi_proquest_miscellaneous_1977218597
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1977218597
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature24652
