Separation of Dual Oxidase 2 and Lactoperoxidase Expression in Intestinal Crypts and Species Differe...
Separation of Dual Oxidase 2 and Lactoperoxidase Expression in Intestinal Crypts and Species Differences May Limit Hydrogen Peroxide Scavenging During Mucosal Healing in Mice and Humans
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US: Oxford University Press
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Language
English
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US: Oxford University Press
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DUOX2 and DUOXA2 form the predominant H2O2-producing system in human colorectal mucosa. Inflammation, hypoxia, and 5-aminosalicylic acid increase H2O2 production, supporting innate defense and mucosal healing. Thiocyanate reacts with H2O2 in the presence of lactoperoxidase (LPO) to form hypothiocyanate (OSCN-), which acts...
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Full title
Separation of Dual Oxidase 2 and Lactoperoxidase Expression in Intestinal Crypts and Species Differences May Limit Hydrogen Peroxide Scavenging During Mucosal Healing in Mice and Humans
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TN_cdi_proquest_miscellaneous_1979962921
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1979962921
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ISSN
1078-0998
E-ISSN
1536-4844
DOI
10.1093/ibd/izx024
