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Structure of a human catalytic step I spliceosome

Structure of a human catalytic step I spliceosome

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1989537506

Structure of a human catalytic step I spliceosome

About this item

Full title

Structure of a human catalytic step I spliceosome

Publisher

United States: The American Association for the Advancement of Science

Journal title

Science (American Association for the Advancement of Science), 2018-02, Vol.359 (6375), p.537-545

Language

English

Formats

Publication information

Publisher

United States: The American Association for the Advancement of Science

More information

Scope and Contents

Contents

Splicing by the spliceosome involves branching and exon ligation. The branching reaction leads to the formation of the catalytic step I spliceosome (C complex). Here we report the cryo-electron microscopy structure of the human C complex at an average resolution of 4.1 angstroms. Compared with the
C complex, the human complex contains 11 additio...

Alternative Titles

Full title

Structure of a human catalytic step I spliceosome

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1989537506

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1989537506

Other Identifiers

ISSN

0036-8075

E-ISSN

1095-9203

DOI

10.1126/science.aar6401

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