Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Lipopolysaccharide (LPS), also known as endotoxin, activates the innate immune response through toll-like receptor 4 (TLR4) and its coreceptor, MD-2. MD-2 has a unique hydrophobic cavity that directly binds to lipid A, the active center of LPS. Tetraacylated lipid IVa, a synthetic lipid A precursor, acts as a weak agonist to mouse TLR4/MD-2, but as...
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Full title
Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
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Record Identifier
TN_cdi_proquest_miscellaneous_1999948809
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1999948809
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1201193109
