Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation
Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation
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United States: American Association for the Advancement of Science
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Language
English
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United States: American Association for the Advancement of Science
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Contents
Threonine is the only amino acid critically required for the pluripotency of mouse embryonic stem cells (mESCs), but the detailed mechanism remains unclear. We found that threonine and S-adenosylmethionine (SAM) metabolism are coupled in pluripotent stem cells, resulting in regulation of histone methylation. Isotope labeling of mESCs revealed that...
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Full title
Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation
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TN_cdi_proquest_miscellaneous_2000383430
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2000383430
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1226603
