Are Astrocytes the Missing Link Between Lack of Brain Aspartoacylase Activity and the Spongiform Leu...
Are Astrocytes the Missing Link Between Lack of Brain Aspartoacylase Activity and the Spongiform Leukodystrophy in Canavan Disease?
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Boston: Springer US
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Language
English
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Publisher
Boston: Springer US
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Canavan disease (CD) is a genetic degenerative brain disorder associated with mutations of the gene encoding aspartoacylase (ASPA). In humans, the CD syndrome is marked by early onset, hydrocephalus, macroencephaly, psychomotor retardation, and spongiform myelin sheath vacuolization with progressive leukodystrophy. Metabolic hallmarks of the diseas...
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Full title
Are Astrocytes the Missing Link Between Lack of Brain Aspartoacylase Activity and the Spongiform Leukodystrophy in Canavan Disease?
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TN_cdi_proquest_miscellaneous_20210614
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_20210614
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ISSN
0364-3190
E-ISSN
1573-6903
DOI
10.1007/s11064-009-9958-z
