Signatures of negative selection in the genetic architecture of human complex traits
Signatures of negative selection in the genetic architecture of human complex traits
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Author / Creator
Zeng, Jian , de Vlaming, Ronald , Wu, Yang , Robinson, Matthew R. , Lloyd-Jones, Luke R. , Yengo, Loic , Yap, Chloe X. , Xue, Angli , Sidorenko, Julia , McRae, Allan F. , Powell, Joseph E. , Montgomery, Grant W. , Metspalu, Andres , Esko, Tonu , Gibson, Greg , Wray, Naomi R. , Visscher, Peter M. and Yang, Jian
Publisher
New York: Nature Publishing Group US
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Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Contents
We develop a Bayesian mixed linear model that simultaneously estimates single-nucleotide polymorphism (SNP)-based heritability, polygenicity (proportion of SNPs with nonzero effects), and the relationship between SNP effect size and minor allele frequency for complex traits in conventionally unrelated individuals using genome-wide SNP data. We appl...
Alternative Titles
Full title
Signatures of negative selection in the genetic architecture of human complex traits
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Record Identifier
TN_cdi_proquest_miscellaneous_2026421676
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2026421676
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-018-0101-4
