Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarizat...
Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization
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Author / Creator
Kang, Sujin , Nakanishi, Yoshimitsu , Kioi, Yoshiyuki , Okuzaki, Daisuke , Kimura, Tetsuya , Takamatsu, Hyota , Koyama, Shohei , Nojima, Satoshi , Nishide, Masayuki , Hayama, Yoshitomo , Kinehara, Yuhei , Kato, Yasuhiro , Nakatani, Takeshi , Shimogori, Tomomi , Takagi, Junichi , Toyofuku, Toshihiko and Kumanogoh, Atsushi
Publisher
New York: Nature Publishing Group US
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English
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Publisher
New York: Nature Publishing Group US
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Contents
Polarization of macrophages into pro-inflammatory or anti-inflammatory states has distinct metabolic requirements, with mechanistic target of rapamycin (mTOR) kinase signaling playing a critical role. However, it remains unclear how mTOR regulates metabolic status to promote polarization of these cells. Here we show that an mTOR–Semaphorin 6D (Sema...
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Full title
Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization
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Record Identifier
TN_cdi_proquest_miscellaneous_2041625274
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2041625274
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-018-0108-0
