Targeting G-quadruplex DNA as cognitive function therapy for ATR-X syndrome
Targeting G-quadruplex DNA as cognitive function therapy for ATR-X syndrome
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Alpha-thalassemia X-linked intellectual disability (ATR-X) syndrome is caused by mutations in
ATRX
, which encodes a chromatin-remodeling protein. Genome-wide analyses in mouse and human cells indicate that ATRX tends to bind to G-rich sequences with a high potential to form G-quadruplexes. Here, we report that
Atrx
mutation induces abe...
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Full title
Targeting G-quadruplex DNA as cognitive function therapy for ATR-X syndrome
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TN_cdi_proquest_miscellaneous_2042750567
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2042750567
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-018-0018-6
