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Reversal of siRNA-mediated gene silencing in vivo

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Reversal of siRNA-mediated gene silencing in vivo

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2042752147

Reversal of siRNA-mediated gene silencing in vivo

About this item

Full title

Reversal of siRNA-mediated gene silencing in vivo

Author / Creator

Zlatev, Ivan , Castoreno, Adam , Brown, Christopher R , Qin, June , Waldron, Scott , Schlegel, Mark K , Degaonkar, Rohan , Shulga-Morskaya, Svetlana , Xu, Huilei , Gupta, Swati , Matsuda, Shigeo , Akinc, Akin , Rajeev, Kallanthottathil G , Manoharan, Muthiah , Maier, Martin A and Jadhav, Vasant

Publisher

New York: Springer New York

Journal title

Nature biotechnology, 2018-07, Vol.36 (6), p.509-511

Language

English

Formats

Articles

Publication information

Publisher

New York: Springer New York

Subjects

More information

Scope and Contents

Contents

Gene silencing by siRNAs
in vivo
is reversed using sequence-specific high-affinity oligonucleotides.
We report rapid, potent reversal of GalNAc-siRNA-mediated RNA interference (RNAi) activity
in vivo
with short, synthetic, high-affinity oligonucleotides complementary to the siRNA guide strand. We found that 9-mers with five locked nu...

Alternative Titles

Full title

Reversal of siRNA-mediated gene silencing in vivo

Authors, Artists and Contributors

Author / Creator

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2042752147

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2042752147

Other Identifiers

ISSN

1087-0156

E-ISSN

1546-1696

DOI

10.1038/nbt.4136

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