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51 results for Manoharan,+Muthiah

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ArticlesPeer ReviewedFull Text
Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown
Author / Creator:Wittrup, Anders ; Ai, Angela ; Liu, Xing ; Hamar, Peter ; Trifonova, Radiana ; Charisse, Klaus ; Manoharan, Muthiah ; Kirchhausen, Tomas ; Lieberman, Judy
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2015-08, Vol.33 (8), p.870-876
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The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
Author / Creator:Akinc, Akin ; Maier, Martin A ; Manoharan, Muthiah ; Fitzgerald, Kevin ; Muthusamy Jayaraman ; Barros, Scott ; Ansell, Steven ; Du, Xinyao ; Hope, Michael J ; Madden, Thomas D ; Mui, Barbara L ; Semple, Sean C ; Tam, Ying K ; Ciufolini, Marco ; Witzigmann, Dominik ; Kulkarni, Jayesh A ; van der Meel, Roy ; Cullis, Pieter R
Publisher:London: Nature Publishing Group
Journal title:Nature nanotechnology, 2019-12, Vol.14 (12), p.1084-1087
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Crystal structure of Middle East respiratory syndrome coronavirus helicase
Author / Creator:Hao, Wei ; Wojdyla, Justyna Aleksandra ; Zhao, Rong ; Han, Ruiyun ; Das, Rajat ; Zlatev, Ivan ; Manoharan, Muthiah ; Wang, Meitian ; Cui, Sheng
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2017-06, Vol.13 (6), p.e1006474-e1006474
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RNAi therapeutics: a potential new class of pharmaceutical drugs
Author / Creator:Bumcrot, David ; Manoharan, Muthiah ; Koteliansky, Victor ; Sah, Dinah W Y
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2006-12, Vol.2 (12), p.711-719
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Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity
Author / Creator:Janas, Maja M ; Schlegel, Mark K ; Harbison, Carole E ; Yilmaz, Vedat O ; Jiang, Yongfeng ; Parmar, Rubina ; Zlatev, Ivan ; Castoreno, Adam ; Xu, Huilei ; Shulga-Morskaya, Svetlana ; Rajeev, Kallanthottathil G ; Manoharan, Muthiah ; Keirstead, Natalie D ; Maier, Martin A ; Jadhav, Vasant
Publisher:London: Nature Publishing Group
Journal title:Nature communications, 2018-02, Vol.9, p.1-10
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ArticlesPeer ReviewedFull Text
Development of Lipidoid Nanoparticles for siRNA Delivery to Neural Cells
Author / Creator:Khare, Purva ; Dave, Kandarp M. ; Kamte, Yashika S. ; Manoharan, Muthiah A. ; O’Donnell, Lauren A. ; Manickam, Devika S.
Publisher:United States: Springer
Journal title:The AAPS journal, 2021-12, Vol.24 (1), p.8-8, Article 8
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An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia
Author / Creator:Sehgal, Alfica ; Barros, Scott ; Ivanciu, Lacramioara ; Cooley, Brian ; Qin, June ; Racie, Tim ; Hettinger, Julia ; Carioto, Mary ; Jiang, Yongfeng ; Brodsky, Josh ; Prabhala, Harsha ; Zhang, Xuemei ; Attarwala, Husain ; Hutabarat, Renta ; Foster, Don ; Milstein, Stuart ; Charisse, Klaus ; Kuchimanchi, Satya ; Maier, Martin A ; Nechev, Lubo ; Kandasamy, Pachamuthu ; Kel'in, Alexander V ; Nair, Jayaprakash K ; Rajeev, Kallanthottathil G ; Manoharan, Muthiah ; Meyers, Rachel ; Sorensen, Benny ; Simon, Amy R ; Dargaud, Yesim ; Negrier, Claude ; Camire, Rodney M ; Akinc, Akin
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2015-05, Vol.21 (5), p.492-497
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Rational design of cationic lipids for siRNA delivery
Author / Creator:Semple, Sean C ; Akinc, Akin ; Chen, Jianxin ; Sandhu, Ammen P ; Mui, Barbara L ; Cho, Connie K ; Sah, Dinah W Y ; Stebbing, Derrick ; Crosley, Erin J ; Yaworski, Ed ; Hafez, Ismail M ; Dorkin, J Robert ; Qin, June ; Lam, Kieu ; Rajeev, Kallanthottathil G ; Wong, Kim F ; Jeffs, Lloyd B ; Nechev, Lubomir ; Eisenhardt, Merete L ; Jayaraman, Muthusamy ; Kazem, Mikameh ; Maier, Martin A ; Srinivasulu, Masuna ; Weinstein, Michael J ; Chen, Qingmin ; Alvarez, Rene ; Barros, Scott A ; De, Soma ; Klimuk, Sandra K ; Borland, Todd ; Kosovrasti, Verbena ; Cantley, William L ; Tam, Ying K ; Manoharan, Muthiah ; Ciufolini, Marco A ; Tracy, Mark A ; de Fougerolles, Antonin ; MacLachlan, Ian ; Cullis, Pieter R ; Madden, Thomas D ; Hope, Michael J
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2010-02, Vol.28 (2), p.172-176
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A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
Author / Creator:Akinc, Akin ; Zumbuehl, Andreas ; Goldberg, Michael ; Leshchiner, Elizaveta S ; Busini, Valentina ; Hossain, Naushad ; Bacallado, Sergio A ; Nguyen, David N ; Fuller, Jason ; Alvarez, Rene ; Borodovsky, Anna ; Borland, Todd ; Constien, Rainer ; de Fougerolles, Antonin ; Dorkin, J Robert ; Narayanannair Jayaprakash, K ; Jayaraman, Muthusamy ; John, Matthias ; Koteliansky, Victor ; Manoharan, Muthiah ; Nechev, Lubomir ; Qin, June ; Racie, Timothy ; Raitcheva, Denitza ; Rajeev, Kallanthottathil G ; Sah, Dinah W Y ; Soutschek, Jürgen ; Toudjarska, Ivanka ; Vornlocher, Hans-Peter ; Zimmermann, Tracy S ; Langer, Robert ; Anderson, Daniel G
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2008-05, Vol.26 (5), p.561-569
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Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
Author / Creator:Wolfrum, Christian ; Shi, Shuanping ; Jayaprakash, K Narayanannair ; Jayaraman, Muthusamy ; Wang, Gang ; Pandey, Rajendra K ; Rajeev, Kallanthottathil G ; Nakayama, Tomoko ; Charrise, Klaus ; Ndungo, Esther M ; Zimmermann, Tracy ; Koteliansky, Victor ; Manoharan, Muthiah ; Stoffel, Markus
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2007-10, Vol.25 (10), p.1149-1157
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ArticlesPeer ReviewedFull Text
Influenza A virus-generated small RNAs regulate the switch from transcription to replication
Author / Creator:Perez, Jasmine T. ; Varble, Andrew ; Sachidanandam, Ravi ; Zlatev, Ivan ; Manoharan, Muthiah ; Garcia-Sastre, Adolfo ; tenOever, Benjamin R. ; Palese, Peter
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-06, Vol.107 (25), p.11525-11530
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Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes
Author / Creator:Clua, Anna ; Grijalvo, Santiago ; Erande, Namrata ; Gupta, Swati ; Yucius, Kristina ; Gargallo, Raimundo ; Mazzini, Stefania ; Manoharan, Muthiah ; Eritja, Ramon
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2022-06, Vol.27 (12), p.3944
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Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
Author / Creator:Frank-Kamenetsky, Maria ; Grefhorst, Aldo ; Anderson, Norma N ; Racie, Timothy S ; Bramlage, Birgit ; Akinc, Akin ; Butler, David ; Charisse, Klaus ; Dorkin, Robert ; Fan, Yupeng ; Gamba-Vitalo, Christina ; Hadwiger, Philipp ; Jayaraman, Muthusamy ; John, Matthias ; Jayaprakash, K. Narayanannair ; Maier, Martin ; Nechev, Lubomir ; Rajeev, Kallanthottathil G ; Read, Timothy ; Röhl, Ingo ; Soutschek, Jürgen ; Tan, Pamela ; Wong, Jamie ; Wang, Gang ; Zimmermann, Tracy ; de Fougerolles, Antonin ; Vornlocher, Hans-Peter ; Langer, Robert ; Anderson, Daniel G ; Manoharan, Muthiah ; Koteliansky, Victor ; Horton, Jay D ; Fitzgerald, Kevin
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2008-08, Vol.105 (33), p.11915-11920
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Correction: Clua et al. Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes. Molecules 2022, 27, 3944
Author / Creator:Clua, Anna ; Grijalvo, Santiago ; Erande, Namrata ; Gupta, Swati ; Yucius, Kristina ; Gargallo, Raimundo ; Mazzini, Stefania ; Manoharan, Muthiah ; Eritja, Ramon
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2022-12, Vol.28 (1), p.98
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Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles
Author / Creator:Mui, Barbara L ; Tam, Ying K ; Jayaraman, Muthusamy ; Ansell, Steven M ; Du, Xinyao ; Tam, Yuen Yi C ; Lin, Paulo JC ; Chen, Sam ; Narayanannair, Jayaprakash K ; Rajeev, Kallanthottathil G ; Manoharan, Muthiah ; Akinc, Akin ; Maier, Martin A ; Cullis, Pieter ; Madden, Thomas D ; Hope, Michael J
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy. Nucleic acids, 2013-12, Vol.2 (12), p.e139-e139, Article e139
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Newsletter articlesFull Text
U.S. Patent and Trademark Office Receives Rajeev Kallanthottathil G, Manoharan Muthiah, Jayaraman Muthusamy, Maier Martin, Nair Jayaprakash K, Butler David and Alnylam Pharmaceuticals Inc's Patent App...
Publisher:New Delhi: Pedia Content Solutions Pvt. Ltd
Journal title:Global IP News. Pharmaceutical Patent News, 2014
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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
Author / Creator:Soutschek, Jürgen ; Akinc, Akin ; Bramlage, Birgit ; Charisse, Klaus ; Constien, Rainer ; Donoghue, Mary ; Elbashir, Sayda ; Geick, Anke ; Hadwiger, Philipp ; Harborth, Jens ; John, Matthias ; Kesavan, Venkitasamy ; Lavine, Gary ; Pandey, Rajendra K. ; Racie, Timothy ; Rajeev, Kallanthottathil G. ; Röhl, Ingo ; Toudjarska, Ivanka ; Wang, Gang ; Wuschko, Silvio ; Bumcrot, David ; Koteliansky, Victor ; Limmer, Stefan ; Manoharan, Muthiah ; Vornlocher, Hans-Peter
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2004-11, Vol.432 (7014), p.173-178
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The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation
Author / Creator:Mobin, Mehrpouya B. ; Gerstberger, Stefanie ; Teupser, Daniel ; Campana, Benedetta ; Charisse, Klaus ; Heim, Markus H. ; Manoharan, Muthiah ; Tuschl, Thomas ; Stoffel, Markus
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-09, Vol.7 (1), p.12848-12848, Article 12848
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Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification
Author / Creator:Chan, Amy ; Liebow, Abigail ; Yasuda, Makiko ; Gan, Lin ; Racie, Tim ; Maier, Martin ; Kuchimanchi, Satya ; Foster, Don ; Milstein, Stuart ; Charisse, Klaus ; Sehgal, Alfica ; Manoharan, Muthiah ; Meyers, Rachel ; Fitzgerald, Kevin ; Simon, Amy ; Desnick, Robert J ; Querbes, William
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy. Nucleic acids, 2015, Vol.4 (11), p.e263-e263, Article e263
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Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain
Author / Creator:Rungta, Ravi L ; Choi, Hyun B ; Lin, Paulo JC ; Ko, Rebecca WY ; Ashby, Donovan ; Nair, Jay ; Manoharan, Muthiah ; Cullis, Pieter R ; MacVicar, Brian A
Publisher:United States: Nature Publishing Group
Journal title:Molecular therapy. Nucleic acids, 2013-12, Vol.2 (11), p.e136
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Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

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The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

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Crystal structure of Middle East respiratory syndrome coronavirus helicase

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RNAi therapeutics: a potential new class of pharmaceutical drugs

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Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

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Development of Lipidoid Nanoparticles for siRNA Delivery to Neural Cells

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An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia

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Rational design of cationic lipids for siRNA delivery

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A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

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Mechanisms and optimization of in vivo delivery of lipophilic siRNAs

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Influenza A virus-generated small RNAs regulate the switch from transcription to replication

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Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes

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Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

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Correction: Clua et al. Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes. Molecules 2022, 27, 3944

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Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

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U.S. Patent and Trademark Office Receives Rajeev Kallanthottathil G, Manoharan Muthiah, Jayaraman Muthusamy, Maier Martin, Nair Jayaprakash K, Butler David and Alnylam Pharmaceuticals Inc's Patent App...

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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

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The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation

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Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification

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Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain

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