Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanis...
Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The huntingtin protein (HTT) contains a polyQ tract preceded by an N-terminal flanking sequence (HTT
NT
) that contributes to HTT aggregation. Now the role of HTT
NT
in aggregation is explored
in vitro
, revealing a complex, multistep pathway initiated when polyQ disrupts HTT
NT
structure, enhancing the latter's assembly int...
Alternative Titles
Full title
Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_20526092
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_20526092
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.1570
