Mixed-model association for biobank-scale datasets
Mixed-model association for biobank-scale datasets
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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[...]we note two caveats regarding mixed-model analysis of binary traits.[...]conditioning on genome-wide signal can produce loss of power under case-control ascertainment2,3; specialized LMM methods are needed for modeling this scenario at scale.BOLT-LMM association statistics computed in this study are currently available for public download at http://data.broadinstitute.org/ alkesgroup/UKBB/ and have been submitted to the UK Biobank Data Showcase. □ Po-Ru Loh1-2·, Gleb Kichaev3, Steven Gazal2-4, Armin P. Schoech2-4-5 and Alkes L. Price2-4-5· 1Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. 2Program in Medical and Population Genetics, Broad Ins...
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Mixed-model association for biobank-scale datasets
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TN_cdi_proquest_miscellaneous_2054952706
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2054952706
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-018-0144-6
