Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS
Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Transgenic mice that model familial (f)ALS, caused by mutations in superoxide dismutase (SOD)1, develop paralysis with pathology that includes the accumulation of aggregated forms of the mutant protein. Using a highly sensitive detergent extraction assay, we traced the appearance and abundance of detergent-insoluble and disulfide cross-linked aggre...
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Full title
Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS
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TN_cdi_proquest_miscellaneous_20800422
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_20800422
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0902505106
