Heterozygous carriage of the alpha1-antitrypsin PiZ variant increases the risk to develop liver cirr...
Heterozygous carriage of the alpha1-antitrypsin PiZ variant increases the risk to develop liver cirrhosis
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Author / Creator
Strnad, Pavel , Buch, Stephan , Hamesch, Karim , Fischer, Janett , Rosendahl, Jonas , Schmelz, Renate , Brueckner, Stefan , Brosch, Mario , Heimes, Carolin V , Woditsch, Vivien , Scholten, David , Nischalke, Hans Dieter , Janciauskiene, Sabina , Mandorfer, Mattias , Trauner, Michael , Way, Michael J , McQuillin, Andrew , Reichert, Matthias C , Krawczyk, Marcin , Casper, Markus , Lammert, Frank , Braun, Felix , von Schönfels, Witigo , Hinz, Sebastian , Burmeister, Greta , Hellerbrand, Claus , Teufel, Andreas , Feldman, Alexandra , Schattenberg, Joern M , Bantel, Heike , Pathil, Anita , Demir, Muenevver , Kluwe, Johannes , Boettler, Tobias , Ridinger, Monika , Wodarz, Norbert , Soyka, Michael , Rietschel, Marcella , Kiefer, Falk , Weber, Thomas , Marhenke, Silke , Vogel, Arndt , Hinrichsen, Holger , Canbay, Ali , Schlattjan, Martin , Sosnowsky, Katharina , Sarrazin, Christoph , von Felden, Johann , Geier, Andreas , Deltenre, Pierre , Sipos, Bence , Schafmayer, Clemens , Nothnagel, Michael , Aigner, Elmar , Datz, Christian , Stickel, Felix , Morgan, Marsha Yvonne , Hampe, Jochen , Berg, Thomas and Trautwein, Christian
Publisher
England: BMJ Publishing Group LTD
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Language
English
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Publisher
England: BMJ Publishing Group LTD
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Scope and Contents
Contents
ObjectiveHomozygous alpha1-antitrypsin (AAT) deficiency increases the risk for developing cirrhosis, whereas the relevance of heterozygous carriage remains unclear. Hence, we evaluated the impact of the two most relevant AAT variants (‘Pi*Z’ and ‘Pi*S’), present in up to 10% of Caucasians, on subjects with non-alcoholic fatty liver disease (NAFLD)...
Alternative Titles
Full title
Heterozygous carriage of the alpha1-antitrypsin PiZ variant increases the risk to develop liver cirrhosis
Authors, Artists and Contributors
Author / Creator
Buch, Stephan
Hamesch, Karim
Fischer, Janett
Rosendahl, Jonas
Schmelz, Renate
Brueckner, Stefan
Brosch, Mario
Heimes, Carolin V
Woditsch, Vivien
Scholten, David
Nischalke, Hans Dieter
Janciauskiene, Sabina
Mandorfer, Mattias
Trauner, Michael
Way, Michael J
McQuillin, Andrew
Reichert, Matthias C
Krawczyk, Marcin
Casper, Markus
Lammert, Frank
Braun, Felix
von Schönfels, Witigo
Hinz, Sebastian
Burmeister, Greta
Hellerbrand, Claus
Teufel, Andreas
Feldman, Alexandra
Schattenberg, Joern M
Bantel, Heike
Pathil, Anita
Demir, Muenevver
Kluwe, Johannes
Boettler, Tobias
Ridinger, Monika
Wodarz, Norbert
Soyka, Michael
Rietschel, Marcella
Kiefer, Falk
Weber, Thomas
Marhenke, Silke
Vogel, Arndt
Hinrichsen, Holger
Canbay, Ali
Schlattjan, Martin
Sosnowsky, Katharina
Sarrazin, Christoph
von Felden, Johann
Geier, Andreas
Deltenre, Pierre
Sipos, Bence
Schafmayer, Clemens
Nothnagel, Michael
Aigner, Elmar
Datz, Christian
Stickel, Felix
Morgan, Marsha Yvonne
Hampe, Jochen
Berg, Thomas
Trautwein, Christian
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2082094777
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2082094777
Other Identifiers
ISSN
0017-5749
E-ISSN
1468-3288
DOI
10.1136/gutjnl-2018-316228
