Long noncoding RNA MALAT1 suppresses breast cancer metastasis
Long noncoding RNA MALAT1 suppresses breast cancer metastasis
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Author / Creator
Kim, Jongchan , Piao, Hai-Long , Kim, Beom-Jun , Yao, Fan , Han, Zhenbo , Wang, Yumeng , Xiao, Zhenna , Siverly, Ashley N. , Lawhon, Sarah E. , Ton, Baochau N. , Lee, Hyemin , Zhou, Zhicheng , Gan, Boyi , Nakagawa, Shinichi , Ellis, Matthew J. , Liang, Han , Hung, Mien-Chie , You, M. James , Sun, Yutong and Ma, Li
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
MALAT1 has previously been described as a metastasis-promoting long noncoding RNA (lncRNA). We show here, however, that targeted inactivation of the
Malat1
gene in a transgenic mouse model of breast cancer, without altering the expression of its adjacent genes, promotes lung metastasis, and that this phenotype can be reversed by genetic add-b...
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Full title
Long noncoding RNA MALAT1 suppresses breast cancer metastasis
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Record Identifier
TN_cdi_proquest_miscellaneous_2126913869
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2126913869
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-018-0252-3
