LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-...
LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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The success of tumor immunotherapy targeting the inhibitory co-receptors PD-1 and CTLA-4 has indicated that many other co-receptors might be potential druggable targets, despite limited information about their functional differences. Here we identified a unique target selectivity for the inhibitory co-receptor LAG-3 that was intrinsic to its immuno...
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Full title
LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII
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TN_cdi_proquest_miscellaneous_2130302838
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2130302838
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-018-0217-9
