Ribosomal protein S7 as a novel modulator of p53–MDM2 interaction: binding to MDM2, stabilization of...
Ribosomal protein S7 as a novel modulator of p53–MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
As a major negative regulator of p53, the MDM2 oncogene plays an important role in carcinogenesis and tumor progression. MDM2 promotes p53 proteasomal degradation and negatively regulates p53 function. The mechanisms by which the MDM2–p53 interaction is regulated are not fully understood, although several MDM2-interacting molecules have recently be...
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Full title
Ribosomal protein S7 as a novel modulator of p53–MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
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TN_cdi_proquest_miscellaneous_21303994
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_21303994
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/sj.onc.1210327
