PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The E3 ubiquitin ligase Parkin mediates the clearance of depolarized mitochondria through the autophagy pathway. PINK1 kinase activity is required for Parkin translocation to depolarized mitochondria where Parkin generates polyubiquitin chains on the voltage-dependent anion channel (VDAC1) to recruit the autophagic adaptor p62/SQSTM1.
Parkinson'...
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Full title
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
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Record Identifier
TN_cdi_proquest_miscellaneous_21320457
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_21320457
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb2012
