Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality
Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
tRNA synthetases (RSs) have been implicated in functions beyond tRNA synthesis, and human TrpRS has been implicated in inhibiting angiogenesis. Tryptophan residues implicated in homotypic interactions on VE-cadherin are now shown to bind the active site of a naturally truncated TrpRS, indicating how this enzyme has been repurposed.
Protein multi...
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Full title
Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality
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TN_cdi_proquest_miscellaneous_21332565
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_21332565
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.1706
