Structural basis of Notch recognition by human γ-secretase
Structural basis of Notch recognition by human γ-secretase
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Author / Creator
Yang, Guanghui , Zhou, Rui , Zhou, Qiang , Guo, Xuefei , Yan, Chuangye , Ke, Meng , Lei, Jianlin and Shi, Yigong
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Aberrant cleavage of Notch by γ-secretase leads to several types of cancer, but how γ-secretase recognizes its substrate remains unknown. Here we report the cryo-electron microscopy structure of human γ-secretase in complex with a Notch fragment at a resolution of 2.7 Å. The transmembrane helix of Notch is surrounded by three transmembrane domains...
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Full title
Structural basis of Notch recognition by human γ-secretase
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Author / Creator
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Record Identifier
TN_cdi_proquest_miscellaneous_2162498384
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2162498384
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-018-0813-8
