Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochon...
Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Cancer-associated fibroblasts (CAFs) are the major cellular stromal component of many solid tumors. In prostate cancer (PCa), CAFs establish a metabolic symbiosis with PCa cells, contributing to cancer aggressiveness through lactate shuttle. In this study, we report that lactate uptake alters the NAD
+
/NADH ratio in the cancer cells, which c...
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Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer
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TN_cdi_proquest_miscellaneous_2202194075
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2202194075
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-019-0805-7
