Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts in...
Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts into therapeutic neurons
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Author / Creator
Jin, Yoonhee , Lee, Jung Seung , Kim, Jin , Min, Sungjin , Wi, Soohyun , Yu, Ji Hea , Chang, Gyeong-Eon , Cho, Ann-Na , Choi, Yeeun , Ahn, Da-Hee , Cho, Sung-Rae , Cheong, Eunji , Kim, Yun-Gon , Kim, Hyong-Pyo , Kim, Yonghwan , Kim, Dong Seok , Kim, Hyun Woo , Quan, Zhejiu , Kang, Hoon-Chul and Cho, Seung-Woo
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Biophysical cues can improve the direct reprogramming of fibroblasts into neurons that can be used for therapeutic purposes. However, the effects of a three-dimensional (3D) environment on direct neuronal reprogramming remain unexplored. Here, we show that brain extracellular matrix (BEM) decellularized from human brain tissue facilitates the plasm...
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Full title
Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts into therapeutic neurons
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TN_cdi_proquest_miscellaneous_2204693463
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2204693463
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ISSN
2157-846X
E-ISSN
2157-846X
DOI
10.1038/s41551-018-0260-8
