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GPAT2 is required for piRNA biogenesis, transposon silencing, and maintenance of spermatogonia in mi...

GPAT2 is required for piRNA biogenesis, transposon silencing, and maintenance of spermatogonia in mi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2204694524

GPAT2 is required for piRNA biogenesis, transposon silencing, and maintenance of spermatogonia in mice

About this item

Full title

GPAT2 is required for piRNA biogenesis, transposon silencing, and maintenance of spermatogonia in mice

Publisher

United States: Society for the Study of Reproduction

Journal title

Biology of reproduction, 2019-07, Vol.101 (1), p.248-256

Language

English

Formats

Publication information

Publisher

United States: Society for the Study of Reproduction

More information

Scope and Contents

Contents

PIWI-interacting RNAs (piRNAs), a subclass of germ cell-specific noncoding small RNAs, are essential for de novo DNA methylation of retrotransposon genes in embryonic testes. PIWIL2/MILI, one of three mouse PIWI family members, is indispensable for piRNA production, DNA methylation of retrotransposons presumably via piRNA, and normal spermatogenesi...

Alternative Titles

Full title

GPAT2 is required for piRNA biogenesis, transposon silencing, and maintenance of spermatogonia in mice

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_2204694524

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2204694524

Other Identifiers

ISSN

0006-3363

E-ISSN

1529-7268

DOI

10.1093/biolre/ioz056

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