Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the thera...
Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index
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Author / Creator
Shen, Wen , De Hoyos, Cheryl L. , Migawa, Michael T. , Vickers, Timothy A. , Sun, Hong , Low, Audrey , Bell, Thomas A. , Rahdar, Meghdad , Mukhopadhyay, Swagatam , Hart, Christopher E. , Bell, Melanie , Riney, Stan , Murray, Susan F. , Greenlee, Sarah , Crooke, Rosanne M. , Liang, Xue-hai , Seth, Punit P. and Crooke, Stanley T.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
The molecular mechanisms of toxicity of chemically modified phosphorothioate antisense oligonucleotides (PS-ASOs) are not fully understood. Here, we report that toxic gapmer PS-ASOs containing modifications such as constrained ethyl (cEt), locked nucleic acid (LNA) and 2′-
O
-methoxyethyl (2′-MOE) bind many cellular proteins with high avidity...
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Full title
Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index
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Record Identifier
TN_cdi_proquest_miscellaneous_2217471660
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2217471660
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/s41587-019-0106-2
