Forskolin attenuates the NLRP3 inflammasome activation and IL-1β secretion in human macrophages
Forskolin attenuates the NLRP3 inflammasome activation and IL-1β secretion in human macrophages
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Background
The treatment of nucleotide-binding domain and leucine-rich repeat containing family, pyrin domain containing 3 (NLRP3) inflammasome-mediated pediatric inflammatory diseases is challenging. Here we studied whether cyclic adenosine monophosphate (cAMP) elevator forskolin could attenuate the nigericin-induced NLRP3-inflammasome activati...
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Full title
Forskolin attenuates the NLRP3 inflammasome activation and IL-1β secretion in human macrophages
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TN_cdi_proquest_miscellaneous_2231989643
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2231989643
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ISSN
0031-3998
E-ISSN
1530-0447
DOI
10.1038/s41390-019-0418-4
