Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy
Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy
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Author / Creator
Zhou, Quan , Shao, Shiqun , Wang, Jinqiang , Xu, Changhuo , Xiang, Jiajia , Piao, Ying , Zhou, Zhuxian , Yu, Qingsong , Tang, Jianbin , Liu, Xiangrui , Gan, Zhihua , Mo, Ran , Gu, Zhen and Shen, Youqing
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
A tumour microenvironment imposes barriers to the passive diffusion of molecules, which renders tumour penetration an unresolved obstacle to an effective anticancer drug delivery. Here, we present a γ-glutamyl transpeptidase-responsive camptothecin–polymer conjugate that actively infiltrates throughout the tumour tissue through transcytosis. When t...
Alternative Titles
Full title
Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy
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Record Identifier
TN_cdi_proquest_miscellaneous_2251124770
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2251124770
Other Identifiers
ISSN
1748-3387
E-ISSN
1748-3395
DOI
10.1038/s41565-019-0485-z
