Safety and efficacy of opicinumab in patients with relapsing multiple sclerosis (SYNERGY): a randomi...
Safety and efficacy of opicinumab in patients with relapsing multiple sclerosis (SYNERGY): a randomised, placebo-controlled, phase 2 trial
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SYNERGY study investigators , Cadavid, Diego , Mellion, Michelle , Hupperts, Raymond , Edwards, Keith R , Calabresi, Peter A , Drulović, Jelena , Giovannoni, Gavin , Hartung, Hans-Peter , Arnold, Douglas L , Fisher, Elizabeth , Rudick, Richard , Mi, Sha , Chai, Yi , Li, Jie , Zhang, Yiwei , Cheng, Wenting , Xu, Lei , Zhu, Bing , Green, Susan M , Chang, Ih , Deykin, Aaron , Sheikh, Sarah I , Agüera Morales, Eduardo , Al Khedr, Abdullatif , Ampapa, Radek , Arroyo, Rafael , Belkin, Martin , Bonek, Robert , Boyko, Alexey , Capra, Ruggero , Centonze, Diego , Clavelou, Pierre , Debouverie, Marc , Drulovic, Jelena , Edwards, Keith , Evangelou, Nikos , Evdoshenko, Evgeniy , Fernández, Oscar , Fernández Sánchez, Victoria , Freedman, Mark , Freedman, Steven , Fryze, Waldemar , Garcia-Merino, Antonio , Gavric-Kezic, Mira , Ghezzi, Angel , Gout, Olivier , Grimaldi, Luigi , Hertmanowska, Hanka , Hintzen, Rogier , Hradilek, Pavel , Hupperts, Raymond , Ilkowski, Jan , Ivashinenkova, Evelina , Izquierdo, Guillermo , Jacques, Francois , Jakab, Gabor , Khabirov, Farit , Klodowska-Duda, Gabriela , Komoly, Samuel , Kostic, Smiljana , Kovarova, Ivana , Kremenchuzky, Marcelo , Laganke, Christopher , LaPierre, Yves , Maciejowski, Maciej , Maison, Francois Grand , Marfia, Girolama Alessandra , Martínez Yélamos, Sergio , Meluzinova, Eva , Montalban, Xavier , Murray, Ronald , Naismith, Robert , Newsome, Scott , Nguyen, Viet , Oreja, Delia , Pardo, Gabriel , Pasechnik, Elena , Patti, Francesco , Potemkowski, Andrzej , Prokopenko, Semen , Qian, Peiqing , Rodríguez-Antigüedad, Alfredo , Rossman, Howard , Rozsa, Csilla , Sánchez López, Fernando , Selmaj, Krzysztof , Silber, Eli , Stepien, Adam , Stepniewska, Anna , Swiat, Maciej , Toncev, Gordana , Tourbah, Ayman , Trushnikova, Tatyana , Uccelli, Antonio , Vachova, Marta , Valis, Martin , Vecsei, Laszlo , Wiertlewski, Sandrine , Zaffaroni, Mauro and Zielinski, Tomasz
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publication information
Publisher
England: Elsevier Ltd
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More information
Scope and Contents
Contents
Opicinumab is a human monoclonal antibody against LINGO-1, an inhibitor of oligodendrocyte differentiation and axonal regeneration. Previous findings suggested that opicinumab treatment might enhance remyelination in patients with CNS demyelinating diseases. We aimed to assess the safety and efficacy of opicinumab in patients with relapsing multipl...
Alternative Titles
Full title
Safety and efficacy of opicinumab in patients with relapsing multiple sclerosis (SYNERGY): a randomised, placebo-controlled, phase 2 trial
Authors, Artists and Contributors
Author / Creator
Cadavid, Diego
Mellion, Michelle
Hupperts, Raymond
Edwards, Keith R
Calabresi, Peter A
Drulović, Jelena
Giovannoni, Gavin
Hartung, Hans-Peter
Arnold, Douglas L
Fisher, Elizabeth
Rudick, Richard
Mi, Sha
Chai, Yi
Li, Jie
Zhang, Yiwei
Cheng, Wenting
Xu, Lei
Zhu, Bing
Green, Susan M
Chang, Ih
Deykin, Aaron
Sheikh, Sarah I
Agüera Morales, Eduardo
Al Khedr, Abdullatif
Ampapa, Radek
Arroyo, Rafael
Belkin, Martin
Bonek, Robert
Boyko, Alexey
Capra, Ruggero
Centonze, Diego
Clavelou, Pierre
Debouverie, Marc
Drulovic, Jelena
Edwards, Keith
Evangelou, Nikos
Evdoshenko, Evgeniy
Fernández, Oscar
Fernández Sánchez, Victoria
Freedman, Mark
Freedman, Steven
Fryze, Waldemar
Garcia-Merino, Antonio
Gavric-Kezic, Mira
Ghezzi, Angel
Gout, Olivier
Grimaldi, Luigi
Hertmanowska, Hanka
Hintzen, Rogier
Hradilek, Pavel
Hupperts, Raymond
Ilkowski, Jan
Ivashinenkova, Evelina
Izquierdo, Guillermo
Jacques, Francois
Jakab, Gabor
Khabirov, Farit
Klodowska-Duda, Gabriela
Komoly, Samuel
Kostic, Smiljana
Kovarova, Ivana
Kremenchuzky, Marcelo
Laganke, Christopher
LaPierre, Yves
Maciejowski, Maciej
Maison, Francois Grand
Marfia, Girolama Alessandra
Martínez Yélamos, Sergio
Meluzinova, Eva
Montalban, Xavier
Murray, Ronald
Naismith, Robert
Newsome, Scott
Nguyen, Viet
Oreja, Delia
Pardo, Gabriel
Pasechnik, Elena
Patti, Francesco
Potemkowski, Andrzej
Prokopenko, Semen
Qian, Peiqing
Rodríguez-Antigüedad, Alfredo
Rossman, Howard
Rozsa, Csilla
Sánchez López, Fernando
Selmaj, Krzysztof
Silber, Eli
Stepien, Adam
Stepniewska, Anna
Swiat, Maciej
Toncev, Gordana
Tourbah, Ayman
Trushnikova, Tatyana
Uccelli, Antonio
Vachova, Marta
Valis, Martin
Vecsei, Laszlo
Wiertlewski, Sandrine
Zaffaroni, Mauro
Zielinski, Tomasz
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_2254503085
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_2254503085
Other Identifiers
ISSN
1474-4422
E-ISSN
1474-4465
DOI
10.1016/S1474-4422(19)30137-1
